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Abstract@#CHUN-7 a Mongolian traditional recipe consisting of 7 medicinal plants is described in the scripture named “༆༆ །།གཡུ་ཐོག་པའི་མཛད་པའི་རིམས སྲུང་ཁྱུ་ལྔ་རྒྱམ་ཏོན་གསལ་བ །།”. The ingredients including Caowu (Radix <i>Aconiti kusnezoffii</i>, CW) and <i>Glehniae Radix</i> (GR) have the effects of suppressing pneumonia, viral pneumonia, relieving pain, stimulating the immune system and reducing fever. The present study was aimed to determine acute and chronic toxicity properties of traditional drug. @*Materials and methods@#CHUN 7 traditional drug were prepared in the traditional medicine sector of the Drug research Institute of Monos group. All WISTAR rats were kept in the same feed, under 12 hours lighting and 12 hours darkness housing. The study of acute and chronic toxicity of CHUN-7 traditional drug was studied by using IP and oral administration were performed on ten WISTAR rats and continued for a total of 28 days with 102.9 mg / kg dose (calculated from human dose: 16.7 mg/kg) in accordance with the WHO General Guidelines for the Evaluation and Study of Traditional Medicine.@*Results@#The result showed no structural changes in the internal organs according to tissue morphology when we administrated CHUN-7 traditional drug.@*Conclusion@#This study showed CHUN-7 traditional drug has no toxic effects to internal organs including liver, kidney, stomach, lungs and heart. Therefore, CHUN-7 traditional drug has potential to use orally without any toxicology.
ABSTRACT
@#Calcium salt composite/calcite or spar is one of traditionally used therapeutic material for hard tissue repair and regeneration due to its abundant calcium content. There are several types of calcite (fluorspar or calcite fluoride, cobaltoan calcite, etc) exist in the nature and their therapeutic effects are different depending on their basic properties. For instance, calcium carbonate based calcite used to treat damaged hard tissue in the traditional medicine. Here, we would like to investigate characterizations of three different types of calcites gathered from the nature. For this purpose, collected calcium salt composites ( calcite, fluorspar, feldspar ) were examined their surface properties, morphology and size by the scanning electron microscopy. Energy-dispersive X-ray spectroscopy was used to determine their elemental analysis and X-ray diffraction was carried out to characterize their crystallinity structure. Based on the calcium contents, calcium carbonate-based calcite was selected to form nano-sized calcite and study their toxicity by using mesenchymal stem cell. Throughout this study, we identified properties of three different calcites and successfully reduced size in nanoscale which helps to use in the future treatment of osteoporosis or to stimulate osteogenesis.
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Background@#The lower socioeconomic status and long distance to eye care facility of the rural dwellers in many communities in developing countries accounts for the increase in the number of preventable and avoidable causes of blindness. It is widely believed that the best option to reduce blindness and visual impairment in these communities is to bring eye care services to their doorsteps in the form of outreach programs. @*Aims@#To assess the pattern of eye diseases presenting at a free eye outreach in a rural community of Mongolia.@*Methods@#A retrospective, descriptive study was carried out on the findings of 2-day outreach programs at Medical Center of Ulziit village, Arkhangai province of Mongolia. Patient history including sociodemographic data and comprehensive eye examination were done in the study group.@*Results@#The most common ocular disorder in the study group was external eye diseases including conjunctivitis. There were more females seen at the free eye outreach clinic and majority of participants were 45-59 years old. @*Conclusion@#In sparsely densely countries like Mongolia, outreach screening programs for ocular morbidity is crucial to decrease low vision and blindness.
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BACKGROUNDScaffolds with the capacity to deliver signaling molecules are attractive for bone regeneration. Here, we developed bioactive siloxane–gelatin hybrid scaffolds via a sol gel process containing stromal derived factor-1 (SDF-1) to recruit osteoprogenitor/stem cells. METHODSThe process was undertaken under room temperature aqueous conditions, which enabled therapeutic molecules to be effectively incorporated. After the sol-gel reaction and lyophilization process, well crosslinked hybrid scaffolds were obtained with porosities of 80–90%.RESULTSDynamic mechanical analysis of the hybrid scaffolds showed significant improvement in storage modulus values (from 10 to 110 kPa) with increasing siloxane content. Target molecule SDF-1 was loaded and released from the scaffolds, and the effects on the homing of mesenchymal stem cell were studied.CONCLUSIONSResults demonstrated significant enhancement in the migration of cells to the SDF-1 loaded scaffolds. Taken together, the developed hybrid scaffolds areconsidered to be useful in loading and delivering signaling molecules such as SDF-1 to recruit osteoprogenitor /mesenchymal stem cells in the bone regeneration process.
ABSTRACT
Background. There are varieties of supports from Mongolian government and health organizations to people with epilepsy. However, epileptics are often socially discriminated due to the negative public attitudes, misconceptions, false beliefs and wrong decisions. Because of this they miss out their right to study or work. Under the aim of providing right information and knowledge about epilepsy to public, carrying out continuous health educational trainings and studies among population is very important to reduce negative attitude towards epilepsy, to prevent from epilepsy stigma and to improve patients’ quality of life.Goal. The objective of this study was to assess the understanding, knowledge and attitude towards epilepsy among population in Ulaanbaatar and to determine some influencing factors.Methods. Questionnaire was carried out within randomly selected 700 people from 6 districts in Ulaanbaatar city.Results. Participants’ age range was from 16 to 64 years and average age was 36.0 (SD 9.34). 64.1% (449) participants out of all had some understanding and knowledge about epilepsy while they possess high school and university educational degree. 42.2% (295) participants had some knowledge about causes of epilepsy, how to react and how to give a first aid for epilepsy patients. However, 57.8% (405) participant out of all involved in the study had not enough knowledge about epilepsy. 29.7% (208) participant had a positive attitude towards epilepsy.ConclusionPersonal age, educational level, information accessed and interaction with people with epilepsy influences to the knowledge about epilepsy.